Every damn game I've played I experienced a glitch. Some of them just put me off.
Skyrim: On the get go the dragon to blow the hole open as you escape never came.
Oblivion: Couldn't talk or do anything. My brother's save file worked though.
Saint's Row: I fell victim to that save error and the no eyeballs and no hips glitch.
There were also a lot of other games where it glitched and I couldn't continue and spent hours trying to figure it out only to check it up and have it tell me that something that was meant to happen never happen. The worst was when I played Medal of Honor. I spent 4 hours stubbornly trying to get one level to work. I became an expert at killing everyone on cue because I memorised the timing by then.
And of course:
Pokemon Blue and Yellow - Mssingo + Mew glitches.